Dosageadministration indication dose acute radiation exposure 6 mg subcutaneously weekly for 2 doses use weight based dosing below for pediatrics weight colony stimulating factors act on hematopoietic cells and stimulate proliferation, differentiation commitment, and some endcell functional activation. Myeloid colony stimulating factors csfs decrease the risk of febrile neutropenia fn from highrisk chemotherapy regimens administered to patients at 20% or greater risk of fn, but little is known about their use in clinical practice. Zarxio, nivestym notice this policy contains information which is clinical in nature. Or the dose required necessitates use of a vial and cannot be met with the fixeddose 300 mcg or 480 mcg prefilled syringes.
The csf family includes csf1 or macrophage csf mcsf, csf2 or granulocyte macrophage csf gmcsf, and csf3 or granulocyte csf gcsf. Or the dose required necessitates use of a vial and cannot be met with the fixeddose 300 mcg. Myeloid growth factors specifically, granulocyte colony stimulating factors gcsfs and granulocytemacrophage colony stimulating factor gmcsfsmay shorten the duration of neutropenia in. It can lead to febrile neutropenia fn, which often requires patients to be hospitalised for intravenous antibiotic therapy. Colonystimulating factor an overview sciencedirect topics. The complementary dnas and genes encoding the four major human myeloid growth factors granulocyte colony stimulating factor, macrophage colony stimulating factor, granulocytemacrophage colony stimulating factor, and interleukin3have all been molecularly cloned. The information in this policy is used by wellmark to make determinations whether medical treatment is covered under the terms of a wellmark members health benefit plan. Individual has a high risk for infectionassociated complications as demonstrated by. However, the role of csf1r signaling in microglial homeostasis in the adult brain is largely unknown. Dosageadministration indication dose acute radiation exposure 6 mg subcutaneously weekly for 2 doses use weight based dosing below for pediatrics weight colony stimulating factors.
Takahashi and associates 1991 have examined the effects of colony stimulating factors on murine osteoclast formation in vitro in a coculture system, and have shown that all these factors can stimulate the growth of osteoclast precursors but, when added simultaneously with l,25oh 2 d 3, inhibit its effects on osteoclast formation. Schrader, in encyclopedia of immunology second edition, 1998. Jun 28, 2019 colony stimulating factors csf are intriguing molecules, which are glycoproteins that control the production and even some functions of granulocytes and macrophages, the immune cells that are. The colonystimulating factor 1 receptor csf1r is a key regulator of myeloid lineage cells. Hematopoietic colonystimulating factors are a diverse group of cytokines now commercially available through recombinant technology. Colony stimulating factor csfmyeloid growth factor mgf clinical guideline. Granulocyte colony stimulating factor gcsf and granulocytemacrophage colony stimulating factor gmcsf have been used successfully to enhance neutrophil recovery in patients with various malignancies undergoing standard or high dose chemotherapy, with or without autologous or allogeneic bone marrow transplantation support, and offer potential. The human hematopoietic colonystimulating factors science. Individual has not received prophylactic therapy with granulocyte colony stimulating factor nccn guidelines myeloid growth factors. Use of colonystimulating factors with chemotherapy. Appendix 1 covered diagnosis codes icd10 icd10 description. What is the role of colonystimulating factor therapy in the.
Feb 01, 2018 colony stimulating factors clinical guideline. White blood cell colony stimulating factors are proven for the following indications. Whereas the role played by cytokines as neuronal mediators is no longer contested, the mechanisms by which cytokines modulate pain processing remain to be elucidated. White blood cell colony stimulating factors are medically necessary when all of the following criteria are met. Or you might have it before and after a stem cell transplant. Granulocyte macrophage colony stimulating factor gmcsf is an antineutropenic, hematopoietic growth factor, which supports survival, clonal expansion, and differentiation of hematopoietic progenitor cells. When conditions are met, we will authorize the coverage of colony stimulating factor.
Pdf the development of the therapeutic roles of filgrastim and sargramostim. Granulocyte colonystimulating factor gcsf is the primary growth factor responsible for the proliferation and differentiation of bone marrow granulocyte progenitors into mature granulocytes. Colony stimulating factors are glycoproteins that promote production of white blood cells mainly granulocytes such as neutrophils, in response to infection. Colonystimulating factors in inflammation and autoimmunity. Colony stimulating factors csfs, also called haematopoietic growth factors, regulate bone marrow production of circulating red and white cells, and platelets. Colony stimulating factors pa summary preferred nonpreferred granix tbo filgrastim leukine sargramostim neupogen filgrastim fulphila pegfilgrastimjmdb neulasta pegfilgrastim nivestym filgrastimaafi zarxio filgrastimsndz. The importance of the granulocytecolony stimulating. Zarxio is the preferred shortacting granulocyte colony stimulating factor product.
Direct proliferative actions of stem cell factor on murine bone marrow cells in vitro. Colonystimulating factors csf are intriguing molecules, which are glycoproteins that control the production and even. Zarxio is the preferred granulocyte colony stimulating factor gcsf. The colonystimulating factors csfs are hematopoietic growth factors. Pdf the four colony stimulating factors csfs, macrophagecsf mcsf or csf1, granulocytecsf gcsf. Granulocyte colony stimulating factor gcsf is a blood growth factor special proteins produced by the body that stimulates the bone marrow to produce more infectionfighting white blood cells called neutrophils. Choose from 127 different sets of colony stimulating factors flashcards on quizlet. Granulocytemacrophage colonystimulating factor wikipedia.
Therapeutic class overview colony stimulating factors. Nov 15, 2015 granulocyte colony stimulating factor gcsf and its related granulocyte macrophage colony stimulating factor gmcsf are glycoproteins belonging to the family of colony stimulating factors csf. The colonystimulating factors have proven utility in a wide spectrum of cytopenic states, and their use is now commonplace. Not receive colony stimulating factor csfs prophylaxis. Colony stimulating factors csfs prior approval criteria august 2017 overview colony stimulating factors csfs are biosynthetic products that stimulate the development of white blood cells such as neutrophils and macrophages infectionfighting blood cells. Colony stimulating factors csfs are secreted glycoproteins that bind to receptor proteins on the surfaces of hemopoietic stem cells, thereby activating intracellular signaling pathways that can cause the cells to proliferate and differentiate into a specific kind of blood cell usually white blood cells. Learn colony stimulating factors with free interactive flashcards. Colony stimulating factors act on hematopoietic cells and stimulate proliferation, differentiation commitment, and some endcell functional activation. Granulocyte colony stimulating factor causes cells from the bone marrow to become mature and activated. Clinical practice guidelines for the use of colony. Member has risk factors for poor outcomes resulting from febrile neutropenia for example.
The macrophage colony stimulating factor, colony stimulating factor 1 csf1, selectively stimulates the survival, proliferation, and differentiation of mononuclear phagocytes from the determined, undifferentiated progenitor cell, through the various intermediate stages of differentiation monoblast promonocyte monocyte, to the mature macrophage stanley et. Colony stimulating factors and myeloid cell biology in. What is the role of colonystimulating factor therapy in. Granulocyte colony stimulating factor gcsf and granulocytemacrophage colony stimulating factor gmcsf are glycosylated polypeptides that induce an increase in the proliferation and maturation of white blood cells including neutrophils and monocytesmacrophages. November 20, 2019 page 2 of 6 neupogen may be considered medically necessary if. Please fax signed forms to paramount at 18442562025. A long acting colony stimulating factor was not received as prophylaxis, and those who previously received zarxio, nivestym, neupogen, or granix will continue with same agent o prophylactic therapy with a colony stimulating factor was not received, and risk factors for poor outcome resulting from febrile neutropenia are present for. Filgrastim, a recombinant granulocyte colonystimulating factor gcsf, and. Recombinant forms of these colony stimulating factors are used to treat severe neutropenia in patients receiving cancer.
Colony stimulating factors were originally detected and assayed by culturing a. Learn vocabulary, terms, and more with flashcards, games, and other study tools. In this study, we have analyzed the involvement of granulocytemacrophage colony stimulating. You may contact paramount by phone at 14198872520 with questions regarding the prior authorization process. The interaction between the immune system and the nervous system has been at the center of multiple research studies in recent years. Request pdf colony stimulating factors in myelodysplastic syndromes the potential for recombinant growth factors to augment hematopoiesis has been extensively investigated with a wide range of. Does not have a history of a contraindication to the prescribed colony stimulating factor. These dna clones have proved valuable for studying the molecular biology of these important regulatory molecules as well as for. Granulocyte colony stimulating factor gcsf or gcsf, also known as colony stimulating factor 3 csf 3, is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream functionally, it is a cytokine and hormone, a type of colony stimulating factor, and is produced by a number of different tissues. Clinical guidelines summary chemotherapyinduced neutropenia cin is a common and serious toxicity of cancer chemotherapy. Colonystimulating factors the myeloid growth factors, and most notably granulocyte colonystimulating factor gcsf, have demonstrated the ability to reduce the incidence and severity of neutropenia and febrile neutropenia while improving chemotherapy dose intensity. Management of chemotherapyinduced neutropenia with colony. Granulocyte colony stimulating factors linkedin slideshare.
Expected prolonged greater than 10 days and profound less than 0. Widely produced in the body, these regulators probably play an important role in resistance to infections. Granulocytemacrophage colony stimulating factor as an. For primary prophylaxis of chemotherapyinduced febrile neutropenia in patients with nonmyeloid malignancies, one of the following. And patient has one or more of the following risk factors for developing infectionrelated complications. The four colony stimulating factors csfs regulate the generation and some functions of granulocytes and macrophages, and recombinant granulocytecsf and granulocytemacrophagecsf are used to. Granulocyte colony stimulating factor gcsf gcsf is a type of growth factor. These substances act in either paracrine or autocrine fashion on marrow cells. A membersrisk for developing neutropenic fever may be assessed prior to the use of colony stimulating factors. Effects of combination with colonystimulating factors. Colony stimulating factors in myelodysplastic syndromes.
Sepsis syndrome age 65 absolute neutrophil count anc colony stimulating factors. The csf family includes csf1 or macrophage csf mcsf, csf2 or granulocyte macrophage csf gmcsf, and csf3 or. Granulocyte colony stimulating factor gcsf and its related granulocyte macrophage colony stimulating factor gmcsf are glycoproteins belonging to the family of colony stimulating factors csf. Guideline aapro ms, bohlius j, cameron da, dal lago l, donnelly jp, kearney n, et al. Hgfs involved in regulating the formation of nonlymphoid blood cells. Colony stimulating factors csfs prior approval criteria.
Human granulocyte colony stimulating factor hgcsf, a neutrophilpromoting cytokine, is an effective therapeutic agent for neutropenia patients who have undergone several cancer treatments. Both infectious diseases society of america idsa and national. Granulocyte colony stimulating factor gcsf, or colony stimulating factor 3, is a glycoprotein cytokine that stimulates formation of granulocyte colonies from the proliferation of a single hematopoietic stem cell. Food and drug administration fda expanded approval of leukine sargramostim for autologous peripheral blood 011927 091925 271923 331925. You might have gcsf after chemotherapy to help your white blood cells recover after treatment. Colony stimulating factors and macrophage heterogeneity. Colonystimulating factors definition of colonystimulating. The granulocytemacrophage colonystimulating factors science.
For the coverage criteria below, in absence of specified drug products, the term colony stimulating factors or csfs will be used in this policy where the coverage criteria apply to all products listed above. Colony stimulating factors pa summary preferred nonpreferred granix tbo filgrastim leukine sargramostim neupogen filgrastim fulphila pegfilgrastimjmdb neulasta pegfilgrastim nivestym filgrastimaafi zarxio filgrastimsndz length of authorization. This may beachieved byevaluating the degree ofmyelosuppression ofthe members chemotherapy regimen inaddition to the presence ofother memberrelated risk factors. We have compared the in vitro properties of mono cytesmacrophages treated with macrophagecolony stimulating factor mcsf or csf1 and granulocyte. We assessed the efficacy and safety of granulocyte colony. The granulocytemacrophage colony stimulating factors are wellcharacterized specific glycoproteins that interact to control the production, differentiation, and function of two related white cell populations of the blood, the granulocytes and monocytemacrophages. Pdf clinical applications of colonystimulating factors. Granulocytemacrophage colony stimulating factor gmcsf, also known as colony stimulating factor 2 csf2, is a monomeric glycoprotein secreted by macrophages, t cells, mast cells, natural killer cells, endothelial cells and fibroblasts that functions as a cytokine.
Genetic loss of the csf1r blocks the normal population of resident microglia in the brain that originates from the yolk sac during early development. The patient has a contraindication or severe intolerance to granix and zarxio. Renewal criteria same as initial prior authorization policy criteria. Is prescribed the colony stimulating factor by or in consultation with a hematologist or oncologist. These dna clones have proved valuable for studying the molecular biology of these. Individual has a high risk for infectionassociated complications as demonstrated by any of the following nccn 2a. The colony stimulating factors csfs, granulocyte macrophagecsf gmcsf, macrophagecsf mcsf or csf1 and granulocytecsf gcsf were first. Patients must have failed, or have a contraindication, or intolerance to zarxio prior to consideration of any other shortacting gcsf product. Gcsfs can be used to treat or prevent infections for patients with a low white cell count. Requests for non preferred agents require trial of zarxio in addition to meeting the clinical criteria detailed below. Request pdf colony stimulating factors in myelodysplastic syndromes the potential for recombinant growth factors to augment hematopoiesis has been extensively investigated with a.
1058 170 401 1349 963 1476 199 1546 692 1073 536 456 513 693 1397 191 998 894 214 1449 798 985 915 1410 1240 695 654 278 1512 1423 428 1187 610 597 854 211 213 1186 79 978 48 658 792 1331 365 1389 1374 411